The USS Spence (DD-512) was a Fletcher-class destroyer of the United States Navy, launched on December 18, 1942. She was named after Rear Admiral William G. Spence and served primarily during World War II. The ship was equipped with advanced weaponry for its time, including torpedoes and anti-aircraft guns, making it a vital asset in naval operations. During her service, the USS Spence participated in several key battles in the Pacific Theater, including the Battle of Leyte Gulf. Tragically, she sank during a typhoon on December 18, 1944, while returning to port, resulting in the loss of many crew members.