The USS S-49 was a United States Navy submarine, part of the S-class fleet. Launched on March 18, 1920, it was designed for coastal defense and reconnaissance missions. The submarine was 219 feet long and had a surface displacement of 1,200 tons. Commissioned in 1924, the USS S-49 served primarily in the Pacific Ocean. It was decommissioned in 1931 and later sold for scrap in 1945. The S-class submarines, including the S-49, played a significant role in the development of submarine technology during the early 20th century, influencing future designs like the USS Nautilus.