The USS Preble (DD-345) was a Clemson-class destroyer of the United States Navy, launched on December 1, 1920. It was named after Commodore Edward Preble, a notable naval officer in the early 19th century. The ship was commissioned on June 30, 1921, and served primarily in the Pacific Fleet during its operational years. Throughout its service, the USS Preble participated in various training exercises and fleet maneuvers. It was decommissioned on November 1, 1931, and later sold for scrap in 1936. The vessel played a role in the interwar period, contributing to naval readiness before World War II.