The USS Preble (DD-198) was a Clemson-class destroyer of the United States Navy, launched on December 1, 1918. It was named after Commodore Edward Preble, a notable naval officer in the early 19th century. The ship was commissioned in 1920 and served primarily in the Atlantic Fleet during its operational years. Throughout its service, the USS Preble participated in various training exercises and fleet maneuvers. It was decommissioned in 1945 and later sold for scrap in 1946. The vessel played a role in the interwar period, contributing to the development of naval tactics and technology.