U.S. Route 49 is a north-south highway in the United States that runs through the state of Mississippi. It stretches approximately 170 miles, connecting the city of Laurel in the south to Memphis, Tennessee in the north. The route serves as a vital corridor for transportation and commerce in the region. Established in 1926, U.S. Route 49 is part of the larger U.S. Highway System. It passes through several towns and cities, including Hattiesburg and Greenville, and is known for its scenic views and cultural significance. The highway plays an important role in connecting communities and facilitating travel.