U.S. Route 45 is a north-south highway that stretches approximately 1,200 miles across the central United States. It begins in New Orleans, Louisiana and travels through several states, including Mississippi, Tennessee, and Illinois, before ending in Michigan. The route serves as an important connector for various cities and towns, facilitating travel and commerce. Along the way, it passes through diverse landscapes, including urban areas, rural farmland, and scenic regions, making it a vital artery for both local and long-distance travelers.