U.S. Route 43 is a north-south highway in the United States that stretches approximately 200 miles. It runs from Mobile, Alabama in the south to Bristol, Virginia in the north, passing through several towns and cities along the way. The route primarily serves as a connector between various local and regional roads. Established in 1926, U.S. Route 43 is part of the larger U.S. Highway System. It traverses diverse landscapes, including urban areas, rural communities, and scenic countryside. The highway plays a significant role in facilitating travel and commerce in the regions it serves.