U.S. Route 322 is a major highway in the United States that runs through the states of Pennsylvania, New Jersey, and Delaware. It spans approximately 200 miles, connecting various towns and cities, and serves as an important transportation route for both local and long-distance travel. The route begins in Cleveland, Ohio, and travels eastward, passing through urban and rural areas. Along the way, it intersects with several other highways, providing access to key destinations and facilitating commerce and tourism in the regions it traverses.