U.S. Route 222 Business is a business route that serves as a local alternative to the main U.S. Route 222 in Pennsylvania. It primarily runs through the city of Reading and connects various neighborhoods and commercial areas, providing access to local businesses and services. The route is designed to facilitate traffic flow within the city while allowing travelers to bypass the more congested sections of the main highway. It plays a crucial role in supporting the local economy by connecting residents to shopping centers, restaurants, and other essential amenities in the Berks County area.