Twelfth Avenue is a major thoroughfare located in various cities, most notably in New York City. In Manhattan, it runs parallel to the Hudson River and is known for its scenic views and proximity to the waterfront. The avenue is part of the city's grid system and features a mix of residential, commercial, and recreational spaces. In addition to its urban significance, Twelfth Avenue is home to several landmarks, including the High Line, a popular elevated park built on a former railway line. The avenue also connects to various neighborhoods, making it an important route for both pedestrians and vehicles in the bustling city.