Toll-like Receptor 1 (TLR1) is a protein found on the surface of certain immune cells. It plays a crucial role in the body's immune response by recognizing specific components of pathogens, such as bacteria and viruses. When TLR1 binds to these components, it activates signaling pathways that help the immune system respond effectively to infections. TLR1 works in conjunction with other Toll-like Receptors, particularly TLR2, to detect a wide range of microbial substances. This collaboration enhances the immune system's ability to identify and combat various pathogens, making TLR1 an essential part of the innate immune system.