Toad venom, specifically from the Colorado River toad (also known as the Sonoran Desert toad), contains a substance called 5-MeO-DMT, which is a powerful psychoactive compound. When the venom is dried and smoked, it can induce intense hallucinations and altered states of consciousness. Users often report profound spiritual experiences and feelings of interconnectedness. The use of toad venom has gained popularity in some alternative and spiritual communities, but it is important to note that it can also pose health risks. The legality of toad venom varies by region, and its extraction can harm the toads, raising ethical concerns about its use.