Tight Junction Proteins
Tight junction proteins are essential components of cell membranes that help form tight junctions, which are specialized connections between adjacent cells. These proteins create a barrier that regulates the passage of substances between cells, maintaining the integrity of tissues and organs. They play a crucial role in controlling what enters and exits the epithelial and endothelial layers of tissues.
Key tight junction proteins include claudins, occludins, and junctional adhesion molecules. These proteins interact with each other and with the cytoskeleton, providing structural support and facilitating communication between cells. Proper functioning of tight junction proteins is vital for maintaining homeostasis and protecting against pathogens.