Thyroid Hormone Receptor Alpha (TRα) is a protein that plays a crucial role in the body's response to thyroid hormones, particularly thyroxine (T4) and triiodothyronine (T3). It is primarily found in various tissues, including the heart, brain, and skeletal muscle, where it helps regulate metabolism, growth, and development. TRα binds to thyroid hormones and influences gene expression, thereby affecting numerous physiological processes. There are two main types of thyroid hormone receptors: Thyroid Hormone Receptor Alpha (TRα) and Thyroid Hormone Receptor Beta (TRβ). TRα is essential for normal development and function, while TRβ is more involved in regulating cholesterol metabolism and heart function. Mutations or dysfunctions in TRα can lead to various health issues, including hypothyroidism and hyperthyroidism.