"The Night Of" is a crime drama miniseries that follows the story of Nasir Khan, a college student who becomes embroiled in a murder case after a night of partying in New York City. He is accused of killing a woman named Andrea Cornish, and the series explores the complexities of the legal system as he navigates his defense. The show delves into the impact of the crime on various characters, including Detective Box, who investigates the case, and John Stone, Nasir's lawyer. It highlights themes of justice, race, and the consequences of a single decision, providing a gripping look at the criminal justice process.