Tetanus-Diphtheria is a combination vaccine that protects against two serious bacterial infections: tetanus and diphtheria. Tetanus, caused by the bacterium Clostridium tetani, leads to painful muscle stiffness and can be life-threatening. Diphtheria, caused by Corynebacterium diphtheriae, results in a thick coating in the throat, making it difficult to breathe and swallow. The vaccine is typically administered in childhood, with booster shots recommended every ten years for continued protection. Vaccination is crucial as both diseases can lead to severe complications and even death. Public health initiatives emphasize the importance of staying up-to-date with the Tetanus-Diphtheria vaccine.