TRα, or Thyroid Hormone Receptor Alpha, is a protein that plays a crucial role in the body's response to thyroid hormones. These hormones are essential for regulating metabolism, growth, and development. TRα is found in various tissues, including the brain, heart, and muscles, where it helps control gene expression in response to thyroid hormone levels. The activity of TRα is vital for maintaining normal physiological functions. When thyroid hormones bind to TRα, it influences the transcription of specific genes, impacting processes such as energy production and heart rate. Abnormalities in TRα function can lead to health issues, including hypothyroidism or hyperthyroidism.