TNFR1, or Tumor Necrosis Factor Receptor 1, is a protein found on the surface of many cells in the body. It plays a crucial role in the immune system by binding to TNF, or Tumor Necrosis Factor, a signaling molecule involved in inflammation and cell death. This interaction helps regulate immune responses and can influence various cellular processes. When TNFR1 is activated, it triggers a cascade of signals that can lead to different outcomes, such as cell survival, apoptosis (programmed cell death), or inflammation. Dysregulation of TNFR1 signaling is associated with several diseases, including autoimmune disorders and cancer, making it an important target for therapeutic research.