TNF, or Tumor Necrosis Factor, is a protein produced by the immune system that plays a crucial role in inflammation and immune responses. It helps regulate various cellular functions, including cell survival, proliferation, and differentiation. TNF is primarily secreted by macrophages, a type of white blood cell, and is involved in the body's defense against infections and diseases. In addition to its protective functions, excessive levels of TNF can lead to chronic inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease. Researchers are studying TNF inhibitors as potential treatments for these conditions, aiming to reduce inflammation and improve patients' quality of life.