T. b. rhodesiense is a subspecies of the parasite Trypanosoma brucei, which causes sleeping sickness in humans. It is primarily found in eastern and southern Africa, transmitted through the bite of the tsetse fly. This subspecies is known for causing the acute form of the disease, which can progress rapidly if left untreated. Infected individuals may experience symptoms such as fever, headaches, and joint pain. As the disease advances, it can affect the central nervous system, leading to confusion, sleep disturbances, and ultimately, coma. Early diagnosis and treatment are crucial for recovery from T. b. rhodesiense infection.