T-Cell Receptor (TCR) Peptide Library Exchange is a method used to study how T-cells recognize and respond to different peptides, which are small fragments of proteins. This process involves creating a diverse library of peptides that can bind to TCRs, allowing researchers to identify which peptides activate specific T-cells. Understanding these interactions is crucial for developing targeted immunotherapies and vaccines. The exchange process typically involves presenting the peptide library to T-cells in a controlled environment, such as a laboratory setting. By analyzing the T-cell responses, scientists can map the specificity of TCRs to various peptides, enhancing our knowledge of the immune system and its role in diseases like cancer and autoimmune disorders.