Systemic Amyloidosis is a rare disease caused by the buildup of abnormal proteins called amyloids in various organs and tissues. These proteins can interfere with normal function, leading to symptoms such as fatigue, swelling, and organ dysfunction. The condition can affect the heart, kidneys, liver, and nervous system, among other areas. Diagnosis typically involves blood tests, urine tests, and imaging studies to assess organ involvement. Treatment options may include medications to reduce amyloid production, chemotherapy, or stem cell transplants, depending on the type and severity of the disease. Early detection is crucial for better outcomes.