Syphilis diagnosis typically involves a combination of medical history, physical examination, and laboratory tests. Healthcare providers look for signs such as sores or rashes and may ask about sexual history. Blood tests are commonly used to detect antibodies produced in response to the Treponema pallidum bacterium, which causes syphilis. In some cases, a sample from a sore may be taken for testing. Early diagnosis is crucial, as untreated syphilis can lead to serious health complications. Regular screening is recommended for individuals at higher risk, including those with multiple sexual partners or a history of sexually transmitted infections (STIs).