Synthetic glucocorticoids are man-made medications that mimic the effects of natural hormones produced by the adrenal glands, specifically cortisol. They are commonly used to reduce inflammation and suppress the immune system in various medical conditions, such as asthma, arthritis, and allergies. These drugs work by binding to glucocorticoid receptors in cells, leading to changes in gene expression that help control inflammation and immune responses. While effective, synthetic glucocorticoids can have side effects, including weight gain, mood changes, and increased risk of infections, especially with long-term use.