Sulfotransferase is an enzyme that plays a crucial role in the process of sulfation, which involves adding a sulfate group to various molecules, including drugs, hormones, and neurotransmitters. This modification helps to increase the solubility of these compounds, making them easier for the body to eliminate. These enzymes are found in various tissues, including the liver, where they help metabolize substances and regulate biological activities. Dysfunction or variations in sulfotransferase activity can impact drug metabolism and may contribute to certain diseases, highlighting their importance in pharmacology and toxicology.