Substance regulation refers to the laws and guidelines that govern the use, distribution, and safety of various substances, including chemicals, drugs, and food additives. These regulations aim to protect public health and the environment by ensuring that substances are safe for consumption and do not pose significant risks. Regulatory agencies, such as the U.S. Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), are responsible for enforcing these regulations. They evaluate substances for safety, efficacy, and environmental impact, and they can impose restrictions or bans on substances that are deemed harmful.