Statistical issues refer to problems that can arise during the collection, analysis, and interpretation of data. These issues can lead to misleading conclusions if not properly addressed. Common problems include sampling bias, where the sample does not accurately represent the population, and confounding variables, which can obscure the true relationship between variables. Another significant issue is the misuse of statistical methods, such as applying inappropriate tests or misinterpreting p-values. This can result in overestimating the strength of relationships or failing to recognize important trends. Addressing these issues is crucial for ensuring the validity and reliability of research findings.