St. Petersburg, Missouri, is an unincorporated community located in the southeastern part of the state. It is situated within Ste. Genevieve County and is part of the Cape Girardeau-Jackson Metropolitan Area. The area is primarily rural, characterized by its scenic landscapes and small-town atmosphere. The community is near the Mississippi River, which plays a significant role in the region's history and economy. St. Petersburg is accessible via local roads and is surrounded by various outdoor recreational opportunities, including parks and nature trails, making it a quiet place for residents and visitors alike.