"Splice" is a science fiction horror film released in 2009, directed by Vincenzo Natali. The story follows two genetic engineers, Clive Nicoli and Elsa Kast, who create a hybrid creature by combining human and animal DNA. Their experiment leads to unexpected consequences as the creature, named Dren, grows rapidly and exhibits unpredictable behavior. As Dren develops, the relationship between the scientists becomes strained, and ethical dilemmas arise regarding their creation. The film explores themes of scientific responsibility, the nature of life, and the consequences of playing God, ultimately leading to a dramatic and unsettling conclusion.