Southeast Missouri is a region located in the southern part of the state of Missouri, known for its diverse landscapes that include rolling hills, rivers, and forests. The area is home to the Mississippi River, which serves as a natural border with Illinois. Major cities in this region include Cape Girardeau and Sikeston, both of which offer a mix of cultural and recreational activities. The economy of Southeast Missouri is primarily based on agriculture, manufacturing, and tourism. The region is known for its rich history, including the Civil War and the Trail of Tears, which adds to its cultural significance. Outdoor activities such as fishing, hiking, and camping are popular due to the abundance of natural resources.