Sodium-glucose transporters (SGLTs) are proteins found in the cell membranes of various tissues, primarily in the intestines and kidneys. They play a crucial role in absorbing glucose from the diet and reabsorbing it from urine. SGLTs use the sodium gradient created by the sodium-potassium pump to transport glucose against its concentration gradient, allowing cells to take in this essential energy source. There are several types of SGLTs, with SGLT1 and SGLT2 being the most studied. SGLT1 is mainly responsible for glucose absorption in the intestines, while SGLT2 is involved in glucose reabsorption in the kidneys. Understanding these transporters is important for developing treatments for conditions like diabetes, where glucose regulation is impaired.