The Sinister Six is a group of supervillains from the Marvel Comics universe, primarily known for their battles against the superhero Spider-Man. The team was created by writer Stan Lee and artist Steve Ditko, first appearing in The Amazing Spider-Man Annual #1 in 1964. The original lineup included villains like Doctor Octopus, Vulture, and Mysterio, who band together to defeat Spider-Man. Over the years, the Sinister Six has seen various members and lineups, often featuring characters such as Electro, Kraven the Hunter, and Sandman. Their goal is typically to eliminate Spider-Man and achieve their own criminal objectives, making them one of his most formidable foes.