Severino di Sant'Agnello was an Italian painter active during the late 15th century. He is known for his contributions to the Renaissance art movement, particularly in the region of Campania. His works often reflect the stylistic influences of his contemporaries, showcasing a blend of realism and religious themes. Di Sant'Agnello's paintings typically feature vibrant colors and intricate details, which were characteristic of the period. While not as widely recognized as some of his peers, his art remains significant for its representation of local culture and devotion, contributing to the rich tapestry of Italian Renaissance art.