The Santee River is a major river located in the eastern United States, primarily in the state of South Carolina. It flows approximately 143 miles from its source at the confluence of the Congaree and Wateree Rivers to its mouth at Santee Bay, where it empties into the Atlantic Ocean. The river is an important waterway for both ecological and recreational purposes. The Santee River basin supports diverse wildlife and habitats, making it a vital area for conservation. It also plays a significant role in local agriculture and industry, providing water resources for irrigation and other uses. The river is popular for activities such as fishing, boating, and birdwatching.