Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease where the body's immune system mistakenly attacks its own tissues and organs. This can lead to inflammation and damage in various parts of the body, including the skin, joints, kidneys, and heart. Symptoms can vary widely and may include fatigue, joint pain, skin rashes, and fever. SLE is more common in women, particularly those of African American, Hispanic, and Asian descent. The exact cause of SLE is not fully understood, but it is believed to involve a combination of genetic, environmental, and hormonal factors. Diagnosis typically involves blood tests and clinical evaluation to assess symptoms and organ involvement.