Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease where the body's immune system mistakenly attacks its own tissues and organs. This can lead to inflammation and damage in various parts of the body, including the skin, joints, kidneys, and heart. Symptoms can vary widely and may include fatigue, joint pain, skin rashes, and fever. The exact cause of SLE is not fully understood, but it is believed to involve a combination of genetic, environmental, and hormonal factors. Diagnosis typically involves a combination of clinical evaluation and laboratory tests, including the detection of specific antibodies in the blood. Treatment focuses on managing symptoms and reducing inflammation.