S-adenosylmethionine, often abbreviated as SAMe, is a naturally occurring compound found in all living cells. It plays a crucial role in the body's methylation processes, which are essential for the synthesis of neurotransmitters, hormones, and DNA. SAMe is formed from the amino acid methionine and ATP (adenosine triphosphate), and it acts as a methyl donor in various biochemical reactions. In addition to its role in metabolism, SAMe is also studied for its potential therapeutic effects. It has been explored as a supplement for conditions like depression, osteoarthritis, and liver disease. Research suggests that SAMe may help improve mood and joint health, although more studies are needed to confirm these benefits.