Route 5S is a state highway located in the state of New York. It runs primarily through Schoharie County and connects the towns of Schoharie and Middleburgh. The route is approximately 12 miles long and serves as a vital link for local traffic, providing access to various communities and attractions in the area. The highway is known for its scenic views, particularly as it passes through the Catskill Mountains. Route 5S is also part of the larger network of roads that facilitate travel and commerce in upstate New York, making it an important route for both residents and visitors.