Reoviridae is a family of double-stranded RNA viruses that are known to infect a variety of hosts, including animals, plants, and fungi. These viruses are characterized by their non-enveloped structure and segmented genome, which allows for genetic reassortment. They are commonly associated with diseases in livestock and can also affect humans, although they typically cause mild infections. The name "Reoviridae" comes from "respiratory enteric orphan viruses," reflecting their initial discovery in respiratory and gastrointestinal infections. Some well-known members of this family include Rotavirus, which is a leading cause of severe diarrhea in children worldwide, and Orbivirus, which can affect livestock and cause significant agricultural losses.