Reed-Sternberg cells are large, abnormal cells typically found in lymphoid tissue. They are a hallmark of Hodgkin lymphoma, a type of cancer that affects the lymphatic system. These cells are characterized by their distinctive appearance, often having two nuclei or a single nucleus with multiple lobes, which makes them easily identifiable under a microscope. The presence of Reed-Sternberg cells indicates the presence of Hodgkin lymphoma and helps in diagnosing the disease. Their origin is believed to be from B lymphocytes, a type of white blood cell involved in the immune response. Understanding these cells is crucial for effective treatment and management of the condition.