Raf Kinase is a type of protein kinase that plays a crucial role in cell signaling pathways, particularly in the MAPK/ERK pathway. This pathway is important for regulating various cellular processes, including growth, division, and survival. Raf Kinase is activated by Ras, a small GTPase, and subsequently activates other proteins in the signaling cascade. There are three main isoforms of Raf Kinase: A-Raf, B-Raf, and C-Raf. Each isoform has distinct functions and regulatory mechanisms. Abnormal activity of Raf Kinase, especially B-Raf, is often associated with certain cancers, making it a target for cancer therapies aimed at inhibiting its activity.