Remote Procedure Call (RPC) is a protocol that allows a program to execute a procedure on a different computer as if it were a local call. This communication method simplifies the process of sending requests and receiving responses over a network, enabling different systems to work together seamlessly. RPC is commonly used in distributed systems, where multiple computers need to collaborate. It abstracts the complexities of network communication, allowing developers to focus on the functionality of their applications. Popular implementations of RPC include gRPC and XML-RPC, which facilitate interactions between services in various programming environments.