Propionate metabolism refers to the process by which the body breaks down propionate, a short-chain fatty acid produced during the fermentation of dietary fibers in the gut. It is primarily generated by gut bacteria and can be absorbed into the bloodstream, where it serves as an energy source for various tissues. Once in the liver, propionate is converted into succinyl-CoA, a key intermediate in the Krebs cycle. This conversion allows propionate to contribute to energy production and the synthesis of glucose, playing a vital role in maintaining metabolic balance and supporting overall health.