Primary Immunodeficiency refers to a group of disorders caused by genetic defects that affect the immune system's ability to function properly. Individuals with this condition are more susceptible to infections because their bodies cannot produce adequate immune responses. These disorders can vary widely in severity and symptoms, often leading to recurrent infections, autoimmune diseases, or other health issues. Diagnosis typically involves blood tests to assess immune function and genetic testing to identify specific defects. Treatment may include immunoglobulin therapy, antibiotics, or in some cases, stem cell transplants. Early detection and management are crucial for improving the quality of life for those affected by Primary Immunodeficiency.