Polysporin is a topical antibiotic ointment used to prevent infection in minor cuts, scrapes, and burns. It contains two active ingredients, bacitracin and polymyxin B, which work together to kill bacteria and promote healing. Polysporin is available over-the-counter and is commonly used in first aid. This ointment is applied directly to the affected area after cleaning it. It helps to keep the wound moist, which can speed up the healing process and reduce scarring. Polysporin is suitable for most people, but those with allergies to its ingredients should avoid using it.