Phosphoribosyl pyrophosphate (PRPP) is a crucial molecule in cellular metabolism, primarily involved in the synthesis of nucleotides and nucleic acids. It serves as a ribose-phosphate donor, facilitating the formation of purines and pyrimidines, which are essential components of DNA and RNA. PRPP is synthesized from ribose-5-phosphate and ATP through the action of the enzyme PRPP synthetase. This reaction adds two phosphate groups to ribose-5-phosphate, creating PRPP. The availability of PRPP is vital for various biochemical pathways, including the salvage pathways for nucleotide synthesis, which recycle nucleotides from degraded DNA and RNA.