Phospholipase A2 (PLA2) is an enzyme that plays a crucial role in the breakdown of phospholipids, which are essential components of cell membranes. By hydrolyzing the fatty acid at the second position of phospholipids, PLA2 releases free fatty acids and lysophospholipids, which can participate in various cellular processes, including inflammation and cell signaling. PLA2 is found in many organisms, including humans, and is involved in several physiological functions. It is particularly important in the immune response, where it helps produce inflammatory mediators. Additionally, different types of PLA2 exist, such as secreted and cytosolic forms, each with specific roles in cellular activities.