Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that play a crucial role in cellular functions such as growth, proliferation, and survival. They are involved in signaling pathways that respond to various stimuli, including hormones and growth factors. By converting phosphatidylinositol into phosphatidylinositol 3-phosphate, PI3Ks help regulate important cellular processes. There are three main classes of PI3Ks, each with distinct functions and regulatory mechanisms. Class I PI3Ks are particularly important in cancer research, as their activation can lead to uncontrolled cell growth. Understanding PI3Ks is essential for developing targeted therapies for various diseases, including cancer and metabolic disorders.