Phosphatidylinositol 3,4-bisphosphate
Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is a phospholipid that plays a crucial role in cellular signaling. It is produced from phosphatidylinositol 4-phosphate (PI4P) through the action of specific kinases. This lipid is involved in various cellular processes, including cell growth, survival, and metabolism.
PI(3,4)P2 acts as a signaling molecule that recruits proteins with specific domains, such as pleckstrin homology (PH) domains, to the cell membrane. This recruitment is essential for the activation of pathways that regulate cellular functions, including those mediated by phosphoinositide 3-kinase (PI3K) and Akt, which are important for cell proliferation and survival.