Peripheral ischemia is a condition where blood flow to the limbs, usually the legs, is reduced due to narrowed or blocked arteries. This reduced blood flow can lead to pain, cramping, and weakness, especially during physical activities like walking. It is often caused by atherosclerosis, where fatty deposits build up in the arteries, or by blood clots. Symptoms of peripheral ischemia may include coldness in the affected limb, changes in skin color, and non-healing wounds. Diagnosis typically involves physical examinations and imaging tests, while treatment options may include lifestyle changes, medications, or surgical procedures to restore blood flow.